the vast majority of biological research historically centers on 2% that codes for functional proteins While human DNA comprises roughly 3 billion base pairs. The remaining 98%, often referred to as non-coding regions, has stayed largely uncharted, Google says. Google has unveiled the AlphaGenome Atlas, an extensive, high-resolution digital directory designed to predict how genetic alterations impact molecular biology throughout the entire human genetic sequence.
It can predict the impact of all 9 billion possible single-letter DNA variants, helping scientists better understand disease.
Google DeepMind chief scientist Demis Hassabis said: “With AlphaFold we mapped the protein universe – now with AlphaGenome Atlas we’re charting the human genome. Freely available for academic research”.
“AlphaGenome Atlas is an interactive resource, mapping the predicted impact of all 9 billion DNA variants.
Google CEO Sundar Pichai said he is excited for what’s to come. To keep scientists from drowning in raw information, the platform introduces the AlphaGenome Variant Impact (AVI) score. This singular metric blends forecasts across both coding segments and non-coding sequences, helping laboratory teams pinpoint the most promising leads without manually reviewing thousands of disparate metrics. It works in a regular web browser, without any coding required, and is free for academic researchers. Excited for the discoveries to come.”