The study, published in the Journal of Clinical Investigation, one of the leading biomedical journals in the world, was jointly led by Simran Singh and Ashish Kumar, under the supervision of Dr Sai Prasad Pydi, assistant professor in the Department of Biological Sciences and Bioengineering at IIT Kanpur.
the validation establishes a foundation for further research into how disrupting the pathway can help preserve insulin secretion in people with obesity and type 2 diabetes While the study does not offer a treatment for diabetes. Now, the IIT Kanpur research has revealed a much faster and more direct exchange of signals.
“We discovered that immune cells that are present next to beta cells can switch off insulin release within minutes,” said Dr Sai Prasad Pydi, who led the study. The findings change our fundamental understanding of how immune cells influence insulin production,” she said. Kanpur: In a breakthrough that changes our understanding of how diabetes develops, researchers at IIT Kanpur have found that immune cells inside the pancreas can switch off insulin release within minutes and have identified the molecular switch that allows them to do it. “And they do it without giving any of the classical inflammation signals we have been studying for decades. The understanding till now was that obesity triggers low-grade inflammation which damages beta cells slowly, over months and years.
The study, published in the Journal of Clinical Investigation, , was jointly led by Simran Singh and Ashish Kumar , under the supervision of Dr Sai Prasad Pydi, assistant professor in the Department of Biological Sciences and Bioengineering at IIT Kanpur.